Extraction of an hyperglycaemic principle from the annatto (Bixa orellana), a medicinal plant in the West Indies. (Record no. 51113)

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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625160201.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-16948
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245 10 - TITLE STATEMENT
Title Extraction of an hyperglycaemic principle from the annatto (Bixa orellana), a medicinal plant in the West Indies.
490 0# - SERIES STATEMENT
Volume/sequential designation Trop Geogr Med., 43(1-2), p.184-188., 1991
520 3# - SUMMARY, ETC.
Summary, etc. The red powdery extract from the seeds of the annatto, Bixa orellana, is a well known food colouring. In an oil suspension it is used as a folk remedy (bush tea)in the West Indies, for diabetes mellitus. Detailed investigations on this extract, yielded a methyl ester, trans-bixin, molecular weight 394 and molecular formula C24H30O4. This purified substance was demonstrated, in anaesthetised mongrel dogs, to cause hyperglycaemia. Concomitant electron microscopy of tissue biopsies, revealed damage to mitochondria and endoplasmic reticulum mainly in liver and pancreas. When dogs were fed on a diet fortified with riboflavin, there was neither demonstrable tissue damage nor associated hyperglycaemia. These findings point to: (i)the potential dangers of informal medications such as 'bush teas'; (ii)the possible role of plant extracts/food additives in the development of diabetes mellitus especially in the undernourished state.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BIXA ORELLANA
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Morrison Ey
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Thompson H
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Pascoe K
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name West M
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Fletcher C.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1jgs-ix7KLTSLo-8dn0vSrJENjzjfglO6/view?usp=drivesdk">https://drive.google.com/file/d/1jgs-ix7KLTSLo-8dn0vSrJENjzjfglO6/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-16948 25.06.2025 25.06.2025 Documentos solicitados