Discovery of a Short-Chain Dehydrogenase from Catharanthus roseus that Produces a New Monoterpene Indole Alkaloid (Record no. 51143)
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| fixed length control field | 01931nam a2200265Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625160201.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-16978 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Discovery of a Short-Chain Dehydrogenase from Catharanthus roseus that Produces a New Monoterpene Indole Alkaloid |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Chembiochem, Feb 9., p.doi: 10.1002/cbic.201700621, 2018 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Plant monoterpene indole alkaloids, a large class of natural products, derive from the biosynthetic intermediate strictosidine aglycone. Strictosidine aglycone, which can exist as a variety of isomers, can be reduced to form numerous different structures. We have discovered a short-chain alcohol dehydrogenase (SDR)from plant producers of monoterpene indole alkaloids (Catharanthus roseus and Rauvolfia serpentina)that reduce strictosidine aglycone and produce an alkaloid that does not correspond to any previously reported compound. Here we report the structural characterization of this product, which we have named vitrosamine, as well as the crystal structure of the SDR. This discovery highlights the structural versatility of the strictosidine aglycone biosynthetic intermediate and expands the range of enzymatic reactions that SDRs can catalyse. This discovery further highlights how a sequence-based gene mining discovery approach in plants can reveal cryptic chemistry that would not be uncovered by classical natural product chemistry approaches. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CATHARANTHUS ROSEUS |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stavrinides Ak |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tatsis Ec |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dang Tt |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Caputi L |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stevenson Cem |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lawson Dm |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schneider B |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schneider B |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1tea3RnjUjlVOxeJV8ks1FKHaMLjacUmM/view?usp=drivesdk">https://drive.google.com/file/d/1tea3RnjUjlVOxeJV8ks1FKHaMLjacUmM/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-16978 | 25.06.2025 | 25.06.2025 | Documentos solicitados |