CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response (Record no. 51304)

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fixed length control field 01297nam a2200229Ia 4500
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control field MX-MdCICY
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control field 20250625160205.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-17141
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Title CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response
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Volume/sequential designation Nature Medicine, 24, p.927-930, 2018
520 3# - SUMMARY, ETC.
Summary, etc. Here, we report that genome editing by CRISPR-Cas9 induces a p53-mediated DNA damage response and cell cycle arrest in immortalized human retinal pigment epithelial cells, leading to a selection against cells with a functional p53 pathway. Inhibition of p53 prevents the damage response and increases the rate of homologous recombination from a donor template. These results suggest that p53 inhibition may improve the efficiency of genome editing of untransformed cells and that p53 function should be monitored when developing cell-based therapies utilizing CRISPR-Cas9.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CRISPR-CAS9
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Personal name Haapaniemi, E.
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Personal name Botla, S.
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Personal name Persson, J.
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Personal name Schmierer, B.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Taipale, J.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/146tLCpYdLB1fxzYd9jMdjyZHMNQKpRrH/view?usp=drivesdk">https://drive.google.com/file/d/146tLCpYdLB1fxzYd9jMdjyZHMNQKpRrH/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-17141 25.06.2025 25.06.2025 Documentos solicitados