Brain structure and response to emotional stimuli as related to gut microbial profiles in healthy women (Record no. 51458)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02746nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625160208.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-17295 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Brain structure and response to emotional stimuli as related to gut microbial profiles in healthy women |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Psychosomatic Medicine, 79(8), p.905-913, 2017 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Objective Brain-gut-microbiota interactions may play an important role in human health and behavior. Although rodent models have demonstrated effects of the gut microbiota on emotional, nociceptive, and social behaviors, there is little translational human evidence to date. In this study, we identify brain and behavioral characteristics of healthy women clustered by gut microbiota profiles. Methods Forty women supplied fecal samples for 16S rRNA profiling. Microbial clusters were identified using Partitioning Around Medoids. Functional magnetic resonance imaging was acquired. Microbiota-based group differences were analyzed in response to affective images. Structural and diffusion tensor imaging provided gray matter metrics (volume, cortical thickness, mean curvature, surface area)as well as fiber density between regions. A sparse Partial Least Square-Discrimination Analysis was applied to discriminate microbiota clusters using white and gray matter metrics. Results Two bacterial genus-based clusters were identified, one with greater Bacteroides abundance (n = 33)and one with greater Prevotella abundance (n = 7). The Prevotella group showed less hippocampal activity viewing negative valences images. White and gray matter imaging discriminated the two clusters, with accuracy of 66.7 per cent and 87.2 per cent, respectively. The Prevotella cluster was associated with differences in emotional, attentional, and sensory processing regions. For gray matter, the Bacteroides cluster showed greater prominence in the cerebellum, frontal regions, and the hippocampus. Conclusions These results support the concept of brain-gut-microbiota interactions in healthy humans. Further examination of the interaction between gut microbes, brain, and affect in humans is needed to inform preclinical reports that microbial modulation may affect mood and behavior. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | METAGENOME |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | OBESITY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | GUT MICROBIAL |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tillisch, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mayer, E. A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gupta, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gill, Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Brazeilles, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Le Nevé, B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Labus, J. S. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1Tbrsttj-dojtFEQZim4E4yYPOuWcOrV4/view?usp=drivesdk">https://drive.google.com/file/d/1Tbrsttj-dojtFEQZim4E4yYPOuWcOrV4/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-17295 | 25.06.2025 | 25.06.2025 | Documentos solicitados |