Anthelmintic effects of Prosopis laevigata n-hexanic extract against Haemonchus contortus in artificially infected gerbils (Meriones unguiculatus) (Record no. 51564)

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control field 20250625160210.0
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-17401
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Title Anthelmintic effects of Prosopis laevigata n-hexanic extract against Haemonchus contortus in artificially infected gerbils (Meriones unguiculatus)
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Volume/sequential designation Journal of helminthology, 84(1), p. 71-75, 2009
520 3# - SUMMARY, ETC.
Summary, etc. The anthelmintic effect of Prosopis laevigata (mezquite)n-hexanic extract was evaluated against Haemonchus contortus endoparasitic stages in artificially infected gerbils (Meriones unguiculatus). Prosopis laevigata leaves were collected from the Sierra de Huautla, Ecological Reserve of the Biosphere, in Morelos State, Mexico; dehydrated under shade and macerated with n-hexane for 3 days, followed by distillation for 8 h. This procedure was repeated three times and the final extract was kept at 4°C. The in vivo effect of the plant extract was evaluated in gerbils artificially infected with H. contortus. Plant extract concentration was 40 mg/ml. Three groups of gerbils were as follows: group 1 (n = 7), P. laevigata extract at 100 ?l intraperitoneally (IP); group 2 (n = 6), control - Tween 20 in water at a single dose of 100 ? l IP; group 3 (n = 8)also served as a control, receiving water only, to determine the mortality due to causes other than the plant extract. An additional group of seven gerbils (group 4)was administered fenbendazole, as a positive control. Five days later the animals were euthanized and stomach and mucosa removed to quantify the nematodes. Data were analysed using the Student's t-test to compare the mean of nematodes obtained in groups 1, 2 and 3. The parasite population in the plant extract treated group 1 was reduced by 42.5percent (P < 0.05)with respect to the control group 2; and when control group 3 was used for comparison the parasitic reduction was estimated as 53.11 percent. This study shows the in vivo anthelmintic effect of P. laevigatan-hexane extract for the first time, using gerbils as an in vivo model, with potential use in sheep.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name De Jesús-Gabino, A. F.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Mendoza-De Gives, P.
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Personal name Salinas-Sánchez, D. O.
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Personal name López-Arellano, M. E.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Liébano-Hernández, E.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Hernández-Velázquez, V. M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Valladares-Cisneros, G.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1q7fsRdP_HRXmxP7hQ7mmttggV3zzf7nU/view?usp=drivesdk">https://drive.google.com/file/d/1q7fsRdP_HRXmxP7hQ7mmttggV3zzf7nU/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-17401 25.06.2025 25.06.2025 Documentos solicitados