The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors (Record no. 51568)
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| fixed length control field | 02426nam a2200445Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625160210.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-17405 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Nature Cell Biology, 19(3), p.238, 2017 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3 or PIP3)mediates signalling pathways as a second messenger in response to extracellular signals. Although primordial functions of phospholipids and RNAs have been hypothesized in the 'RNA world', physiological RNA-phospholipid interactions and their involvement in essential cellular processes have remained a mystery. We explicate the contribution of lipid-binding long non-coding RNAs (lncRNAs)in cancer cells. Among them, long intergenic non-coding RNA for kinase activation (LINK-A)directly interacts with the AKT pleckstrin homology domain and PIP3 at the single-nucleotide level, facilitating AKT-PIP3 interaction and consequent enzymatic activation. LINK-A-dependent AKT hyperactivation leads to tumorigenesis and resistance to AKT inhibitors. Genomic deletions of the LINK-A PIP3-binding motif dramatically sensitized breast cancer cells to AKT inhibitors. Furthermore, meta-analysis showed the correlation between LINK-A expression and incidence of a single nucleotide polymorphism (rs12095274: A > G), AKT phosphorylation status, and poor outcomes for breast and lung cancer patients. PIP3-binding lncRNA modulates AKT activation with broad clinical implications. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lin, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hu, Q. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xing, Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ma, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yao, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liang, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Park, P. K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marks, J. R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhou, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhou, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hung, M-C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liang, H., |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hu, Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shen, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hawke, D. H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Han, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhou, Y |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lin, C |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yang, L. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1xccpj-9jebyHZjQlVp-SCMoj73q7Hy7c/view?usp=drivesdk">https://drive.google.com/file/d/1xccpj-9jebyHZjQlVp-SCMoj73q7Hy7c/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-17405 | 25.06.2025 | 25.06.2025 | Documentos solicitados |