MARC details
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02429nam a2200325Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625160210.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-17417 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Thermosensitive chitosan/glycerophosphate-based hydrogel and its derivatives in pharmaceutical and biomedical applications |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Expert Opin Drug Delivery, 11(2), p.249-67, 2014 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
INTRODUCTION Thermogelling chitosan (CS)/glycerophosphate (GP)solutions have been reported as a new type of parenteral in situ forming depot system. These free-flowing solutions at ambient temperature turn into semi-solid hydrogels after parenteral administration. AREAS COVERED: Formulation parameters such as CS physico-chemical characteristics, CS/gelling agent ratio or pH of the system, were acknowledged as key parameters affecting the solution stability, the sol/gel transition behavior and/or the final hydrogel structure. We discuss also the use of the standard CS/GP thermogels for various biomedical applications, including drug delivery and tissue engineering. Furthermore, this manuscript reviews the different strategies implemented to improve the hydrogel characteristics such as combination with carrier particles, replacement of GP, addition of a second polymer and chemical modification of CS. EXPERT OPINION: The recent advances in the formulation of CS-based thermogelling systems already overcame several challenges faced by the standard CS/GP system. Dispersion of drug-loaded carrier particles into the thermogels allowed achieving prolonged release profiles for low molecular weight drugs; incorporation of an additional polymer enabled to strengthen the network, while the use of chemically modified CS led to enhanced pH sensitivity or biodegradability of the matrix. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CHITOSAN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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DRUG DELIVERY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
GLYCEROPHOSPHATE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
HYDROGEL |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN-SITU FORMING DEPOT |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
SUSTAINED RELEASE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
THERMOSENSITIVE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TISSUE ENGINEERING |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Supper S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Anton N, |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Seidel N, |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Riemenschnitter M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Curdy C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Vandamme T. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1M5TPhxNeHHde_ZbU05jH9krQiYNeRbCC/view?usp=drivesdk">https://drive.google.com/file/d/1M5TPhxNeHHde_ZbU05jH9krQiYNeRbCC/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
