GABA-modulating bacteria of the human gut microbiota. (Record no. 51924)
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| fixed length control field | 02820nam a2200385Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625160217.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-17762 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | GABA-modulating bacteria of the human gut microbiota. |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Nature MicroBiology, 4(3), p.396, 2019 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The gut microbiota affects many important host functions, including the immune response and the nervous system. However, while substantial progress has been made in growing diverse microorganisms of the microbiota, 23-65percent of species residing in the human gut remain uncultured, which is an obstacle for understanding their biological roles. A likely reason for this unculturability is the absence in artificial media of key growth factors that are provided by neighbouring bacteria in situ. In the present study, we used co-culture to isolate KLE1738, which required the presence of Bacteroides fragilis to grow. Bioassay-driven purification of B. fragilis supernatant led to the isolation of the growth factor, which, surprisingly, is the major inhibitory neurotransmitter GABA (?-aminobutyric acid). GABA was the only tested nutrient that supported the growth of KLE1738, and a genome analysis supported a GABA-dependent metabolism mechanism. Using growth of KLE1738 as an indicator, we isolated a variety of GABA-producing bacteria, and found that Bacteroides ssp. produced large quantities of GABA. Genome-based metabolic modelling of the human gut microbiota revealed multiple genera with the predicted capability to produce or consume GABA. A transcriptome analysis of human stool samples from healthy individuals showed that GABA-producing pathways are actively expressed by Bacteroides, Parabacteroides and Escherichia species. By coupling 16S ribosmal RNA sequencing with functional magentic resonance imaging in patients with major depressive disorder, a disease associated with an altered GABA-mediated response, we found that the relative abundance levels of faecal Bacteroides are negatively correlated with brain signatures associated with depression. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Strandwitz P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kim Kh. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Terekhova D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liu Jk. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sharma A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Levering J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mcdonald D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mcdonald D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ramadhar Tr. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lekbua A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mroue N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liston C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stewart E. J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dubin Mj |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zengler K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Knight R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gilbert J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Clardy J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lewis K. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1n-kGWYu_4tSdVZZAm7slgXVDZqOZizqu/view?usp=drivesdk">https://drive.google.com/file/d/1n-kGWYu_4tSdVZZAm7slgXVDZqOZizqu/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-17762 | 25.06.2025 | 25.06.2025 | Documentos solicitados |