MARC details
| 000 -LEADER |
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| fixed length control field |
01728nam a2200265Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625160219.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-17878 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Isolation of 4, 4?-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma. |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
The Journal of antibiotics, 72(1), p.34, 2019 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
4,4?-bond secalonic acid D (4,4?-SAD)is a known compound isolated from the marine-derived fungus Penicillium oxalicum. No study about the antitumor effect of this compound has been reported, except for a few focusing on its bactericidal properties. Herein, we performed an in vitro biology test and found that 4,4?-SAD stimulated the apoptosis of tumor cells in the human hepatocellular carcinoma cell lines PLC/PRF/5 and HuH-7 by activating caspase-3, caspase-8, caspase-9, PARP, p53, and cyclin B1, as well as by regulating the Bax/Bcl-2 ratio. In vivo studies showed that 4,4?-SAD had antitumor efficacy in H22 cell xenograft model. Immunohistochemical analysis revealed that 4,4?-SAD could regulate Bax expression, which is a biomarker of tumor growth. In summary, 4,4?-SAD significantly inhibited tumor growth both in vivo and in vitro. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
FUNGUS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PENICILLIUM OXALICUM |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CANCER |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chen, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Li, Y. P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Li, X. X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Lu, Z. H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zheng, Q. H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Liu, Q. Y. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1brn43dCWkFGUjZ4cuV3N4qmbsUthrxRd/view?usp=drivesdk">https://drive.google.com/file/d/1brn43dCWkFGUjZ4cuV3N4qmbsUthrxRd/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
