Synthesis and cytotoxic evaluation of usnic acid benzylidene derivatives as potential anticancer agents (Record no. 52095)

MARC details
000 -LEADER
fixed length control field 01495nam a2200289Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625160220.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-17935
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
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245 10 - TITLE STATEMENT
Title Synthesis and cytotoxic evaluation of usnic acid benzylidene derivatives as potential anticancer agents
490 0# - SERIES STATEMENT
Volume/sequential designation Natural Product Research, p.1-10 https://doi.org/10.1080/14786419.2019.1639176, 2019
520 3# - SUMMARY, ETC.
Summary, etc. A series of usnic acid benzylidene derivatives (groups I-V)were designed, synthesized and evaluated for their anticancer activity in the search for potentially new anticancer agents. Compounds 1a, 5b, 2b, 2e and 2f exhibited the most potent cytotoxcity against K562 cell line with IC50 values of 10.0?±?3.6, 5.6?±?0.4, 8.8?±?1.0, 4.5?±?0.1 and 8.4?±?0.4??M, respectively. It is noteworthy that compound 2e displayed potent cytotoxicity against K562 cells without any cytotoxic effect on HEK293 normal cell line.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ALDOL CONDENSATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BENZYLIDENE DERIVATIVE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CYTOTOXICITY
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element USNIC ACID
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Nguyen, V. K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sichaem, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Nguyen, H. H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Nguyen, X. H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Huynh, T. T. L.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Nguyen, T. P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Nguyen, K. P. P.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1DowroXizg8tV5bW4k_Vukk4iXv-hB8ly/view?usp=drivesdk">https://drive.google.com/file/d/1DowroXizg8tV5bW4k_Vukk4iXv-hB8ly/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-17935 25.06.2025 25.06.2025 Documentos solicitados