Cross-linked hyaluronic acid-based flexible cell delivery system: application for chondrogenic differentiation. (Record no. 52442)

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fixed length control field 02279nam a2200289Ia 4500
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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625160226.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-18290
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245 10 - TITLE STATEMENT
Title Cross-linked hyaluronic acid-based flexible cell delivery system: application for chondrogenic differentiation.
490 0# - SERIES STATEMENT
Volume/sequential designation Colloids and Surfaces B: Biointerfaces, 91, p.106-113, 2012
520 3# - SUMMARY, ETC.
Summary, etc. A flexible porous three-dimensional (3D)matrix of hyaluronic acid (HA)was developed to improve the rigidity problems of the previously developed 3D systems. The viscoelasticity of the new formulation was expected to facilitate the differentiation of chondrocytes for the treatment of osteoarthritis (OA). The 3D matrix was fabricated using poly (ethylene glycol)diglycidyl ether (PEGDG)as a cross-linker, which was identified by Fourier transform infrared spectroscopy (FT-IR). The porous structure of the matrix was observed by scanning electron microscopy (SEM). The rheological characteristics of the fabricated HA matrix, that transforms to a gel-like semisolid state in the culture media with and without chondrocytes, were investigated. The proliferation of chondrocytes in the matrix increased according to the cultivation time. The chondrogenic differentiation of chondrocytes in the matrix also increased as determined by reverse transcription-polymerase chain reaction (RT-PCR)and by quantification of sulfated glycosaminoglycan (s-GAG). Moreover, safranin-O staining demonstrated that chondrocytes in the matrix produced extracellular matrix (ECM)after 28 days of culture. Thus, these results show that the "flexible" porous 3D cell delivery system based on HA could improve the clinical efficiency in OA treatment.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CHONDROCYTE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element DIFFERENTIATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HYALURONIC ACID-BASED MATRIX
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PROLIFERATION
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Hwang, H. D.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Cho, H. J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Balakrishnan, P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Chung, C. W.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Yoon, I. S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Oh, Y. K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kim, D. D.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1tPsh5cZTPeBJO85qFU4s_3IQbQN45nRy/view?usp=drivesdk">https://drive.google.com/file/d/1tPsh5cZTPeBJO85qFU4s_3IQbQN45nRy/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-18290 25.06.2025 25.06.2025 Documentos solicitados