MARC details
| 000 -LEADER |
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| fixed length control field |
02274nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625160227.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-18315 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
New cassane-type diterpenoids from kernels of Caesalpinia bonduc (Linn.)Roxb. and their inhibitory activities on phosphodiesterase (PDE)and nuclear factor-kappa B (NF-?B)expression. |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Bioorganic Chemistry, 96, p.103573, 2020 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
In this paper, chemical investigation on the chloroform soluble fraction of seed kernels of Caesalpinia bonduc resulted in the isolation of five new cassane diterpenoids: norcaesalpinin O (1), norcaesalpinin P (2), caesalpinin MQ (3), caesall O/P (4/5)and seven known compounds (6-12). Compounds structures were elucidated by 1H NMR, 13C NMR, 2D NMR, HR-MS and ECD (electronic circular dichroism)spectral analysis. The characters for new compounds with the presence of an aromatized C ring or demethyl group at C-17 position in the structures were found. By means of bioactive screenings, the inhibitory effect on type-4 phosphodiesterase (PDE4, the target protein of asthma disease)and nuclear factor-kappa B (NF-?B)expression were valued. Compound 1 was found to exhibit moderate inhibitory activity on PDE4 and much better binding affinity than other structures by docking studies for interaction analyzing. Compounds 6, 10 and 11 displayed considerable inhibitory strength against NF-?B expression with inhibitory ratio 48.6 per cent, 42.9 per cent and 37.1 per cent at 10 µM, respectively. The isolation of cassane-type diterpenoids with anti-inflammation activity from C. bonduc implied that this plant might be a good source for anti-inflammation agents finding. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CAESALPINIA BONDUC |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
LEGUMINOSAE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CASSANE DITERPENOIDS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TYPE-4 PHOSPHODIESTERASE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
NF-?B |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Liu, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wang, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Qi, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Shen, X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wang, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Jing, W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Gao, H. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1pAVJu0NX0qkgPcwSnULA07CoiIhffiHn/view?usp=drivesdk">https://drive.google.com/file/d/1pAVJu0NX0qkgPcwSnULA07CoiIhffiHn/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
