MARC details
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02444nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20250625160227.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-18320 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Preparation of chitosan-TPP nanoparticles using microengineered membranes-Effect of parameters and encapsulation of tacrine. |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Colloids and Surfaces A: PhysicoChemical and Engineering Aspects, 482, p.34-43, 2015 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Chitosan nanoparticles were prepared by a novel technique based on ionic gelation using sodium tripolyphosphate (TPP)as cross-linking agent. In this method, the TPP solution flows through the pores of a microengineered membrane into the chitosan solution put in a stirred cell. It is shown that favorable micromixing conditions are created on top of the membrane surface to form chitosan-TPP nanoparticles. The influence of several formulation parameters (chitosan and TPP concentrations, ratio between volumes of the two solutions, pH of the two solutions, chitosan molecular weight)and process parameters (membrane characteristics, injection speed, stirring rate)were investigated. Under optimum conditions, chitosan-TPP nanoparticles had a mean size around 90-100 nm, polydispersity index around 0.22, and zeta potential close to +31 mV. The encapsulation of the anti-Alzheimer's drug tacrine did not change the mean size and polydispersity index of unloaded nanoparticles, whereas the zeta potential was increased to +38 mV due to the positively charge of tacrine. Under optimum conditions, tacrine encapsulation efficiency into nanoparticles was found equal to 66.1 percent. In addition, chitosan-TPP nanoparticles were shown to be stable at least during 25 days in an acidic medium at 4 or 25 °C. This study demonstrates that ionic gelation using a stirred cell with microengineered membrane is a suitable technique for preparation of chitosan-TPP nanoparticles. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CHITOSAN NANOPARTICLES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IONIC GELATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MEMBRANE EMULSIFICATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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MEMBRANE CONTACTOR |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TACRINE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ALZHEIMER'S DISEASE |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hassani, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Laouini, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Fessi, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Charcosset, C. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1lcLheBaoyu3zFuHWoGLyc1KJpmFKYeml/view?usp=drivesdk">https://drive.google.com/file/d/1lcLheBaoyu3zFuHWoGLyc1KJpmFKYeml/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
