Hemostatic granules and dressing prepared from formulations of carboxymethyl cellulose, kappa-carrageenan and polyethylene oxide crosslinked by gamma radiation. (Record no. 52497)

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fixed length control field 02188nam a2200301Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625162410.0
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Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-18345
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245 10 - TITLE STATEMENT
Title Hemostatic granules and dressing prepared from formulations of carboxymethyl cellulose, kappa-carrageenan and polyethylene oxide crosslinked by gamma radiation.
490 0# - SERIES STATEMENT
Volume/sequential designation Radiation Physics and Chemistry, 144, p.180-188, 2018
520 3# - SUMMARY, ETC.
Summary, etc. Uncontrolled hemorrhage remains a persistent problem especially in anatomical areas where compression and tourniquet cannot be applied. Hemostatic agents are materials which can achieve control of bleeding in acute, life-threatening traumatic coagulopathy. In this study, we prepared biocompatible hydrogel-based hemostat crosslinked by ionizing radiation. Granules made from carboxymethyl cellulose and dressing from kappa carrageenan and polyethylene oxide were characterized by FT-IR, SEM, and gel analysis. Gamma radiation with a dose of 25 kGy was used for sterilization process. Stability studies indicate that the products remain effective with a shelf life of up to 18 months based on accelerated aging. Both hemostatic agents were demonstrated to be effective in vitro blood clotting assays showing a low blood clotting index, high platelet adhesion capacity and accelerated clotting time. Hemostat granules and dressing were also used in a femoral artery rat bleeding model where hemorrhage control was achieved in 90 s without compression and resulted in 100 per cent survival rate after a 7 and 14-day observation.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HEMOSTATIC AGENTS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HEMORRHAGE CONTROL
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CARBOXYMETHYL CELLULOSE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element KAPPA CARRAGEENAN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element POLYETHYLENE OXIDE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element RADIATION CROSSLINKING
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Barba, B. J. D.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Aranilla, C. T.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Relleve, L. S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Cruz, V. R. C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Vista, J. R.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Abad, L. V.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1FvOvN2YtptRjGch1DaAXCTryMfXQk3-J/view?usp=drivesdk">https://drive.google.com/file/d/1FvOvN2YtptRjGch1DaAXCTryMfXQk3-J/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-18345 25.06.2025 25.06.2025 Documentos solicitados