Hemostatic efficacy evaluation of radiation crosslinked carboxymethyl kappa-carrageenan and chitosan with varying degrees of substitution. (Record no. 52498)

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control field 20250625162410.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-18346
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245 10 - TITLE STATEMENT
Title Hemostatic efficacy evaluation of radiation crosslinked carboxymethyl kappa-carrageenan and chitosan with varying degrees of substitution.
490 0# - SERIES STATEMENT
Volume/sequential designation Radiation Physics and Chemistry, 124, p.124-129, 2016
520 3# - SUMMARY, ETC.
Summary, etc. Carboxymethyl derivatives of kappa-carrageenan and chitosan, with varying degrees of substitution, were synthesized by multi-step reaction technique and evaluated for hemostatic efficacy through in vitro assays. FTIR analysis confirmed the presence of carboxymethyl group while 1H NMR spectroscopy indicated degrees of substitution ranging from 1.15-1.58 and 0.45-0.51 for carboxymethyl-?-carrageenan and carboxymethylchitosan, respectively. Derivatives formed into paste consistency (30 per cent w/v)were successfully crosslinked by gamma irradiation at 30 kGy. The data obtained from whole blood clotting and platelet adhesion assays showed a significant increase in hemostatic capability of ?-carrageenan and chitosan as a consequence of carboxymethylation and crosslinking modifications. In addition, the level of efficacy was comparable to that of a chitosan-based commercial product. These results suggest the potential of ?-carrageenan and chitosan derivatives for development into hemostatic agents.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element KAPPA-CARRAGEENAN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CHITOSAN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CARBOXYMETHYLATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element RADIATION CROSSLINKING
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HEMOSTATIC EFFICACY
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Tranquilan-Aranilla, C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Barba, B. J. D.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Vista, J. R. M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Abad, L. V.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1VJNfEs7Hz-H2UxyeeRZb98jS0P1T14vr/view?usp=drivesdk">https://drive.google.com/file/d/1VJNfEs7Hz-H2UxyeeRZb98jS0P1T14vr/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-18346 25.06.2025 25.06.2025 Documentos solicitados