Labeling efficiency and biodistribution of Technetium-99m labeled nanoparticles: interference by colloidal tin oxide particles. (Record no. 52587)

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control field MX-MdCICY
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control field 20250625162412.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-18435
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245 10 - TITLE STATEMENT
Title Labeling efficiency and biodistribution of Technetium-99m labeled nanoparticles: interference by colloidal tin oxide particles.
490 0# - SERIES STATEMENT
Volume/sequential designation International Journal of pharmaceutics, 289(1-2), p.189-195., 2005
520 3# - SUMMARY, ETC.
Summary, etc. The interference of colloidal tin oxides on the biodistribution of 99mTechnetium radiolabeled chitosan nanoparticles has been overcome by using sodium borohydride instead of commonly used stannous salts as reducing agent for the reduction of 99mTc (VII)to lower valency states. Biodistribution of radiolabeled chitosan nanoparticles prepared by using stannous chloride method revealed localization of the radioactivity mainly in the liver and spleen while that of radiolabeled chitosan nanoparticles prepared by using sodium borohydride method manifested the presence of radioactivity in blood up to an extent of 10 percent even after 2 h. Interestingly, the reduction of radioactivity in the latter case with the progress of time was not manifested through an increase in activity in the liver. Rather, a time dependent increased accumulation of radioactive materials was observed in the stomach. From the results it has been concluded that the biodistribution is strongly influenced by the presence of colloidal particles of tin oxides and 99mTc labeled chitosan nanoparticles are RES evading and long circulating in blood when Tc (VII)is reduced by sodium borohydride and not by stannous chloride during radiolabeling process.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element 99MTC
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CHITOSAN NANOPARTICLES
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GAMMA SCINTIGRAPHY
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HYDROGELS
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Banerjee, T.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Singh, A. K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sharma, R. K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Maitra, A. N.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1n4ZyKshq2FlCW0tK-sbsluXMoMdoKBip/view?usp=drivesdk">https://drive.google.com/file/d/1n4ZyKshq2FlCW0tK-sbsluXMoMdoKBip/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-18435 25.06.2025 25.06.2025 Documentos solicitados