MARC details
| 000 -LEADER |
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| fixed length control field |
02815nam a2200289Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625162413.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-18489 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Scaffolds from block polyurethanes based on poly (?-caprolactone)(PCL)and poly (ethylene glycol)(PEG)for peripheral nerve regeneration. |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
BioMaterials, 35(14), p.4266-4277, 2014 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Nerve guide scaffolds from block polyurethanes without any additional growth factors or protein were prepared using a particle leaching method. The scaffolds of block polyurethanes (abbreviated as PUCL-ran-EG)based on poly(?-caprolactone)(PCL-diol)and poly(ethylene glycol)(PEG)possess highly surface-area porous for cell attachment, and can provide biochemical and topographic cues to enhance tissue regeneration. The nerve guide scaffolds have pore size 1-5 µm and porosity 88percent. Mechanical tests showed that the polyurethane nerve guide scaffolds have maximum loads of 4.98 ± 0.35 N and maximum stresses of 6.372 ± 0.5 MPa. The histocompatibility efficacy of these nerve guide scaffolds was tested in a rat model for peripheral nerve injury treatment. Four types of guides including PUCL-ran-EG scaffolds, autograft, PCL scaffolds and silicone tubes were compared in the rat model. After 14 weeks, bridging of a 10 mm defect gap by the regenerated nerve was observed in all rats. The nerve regeneration was systematically characterized by sciatic function index (SFI), histological assessment including HE staining, immunohistochemistry, ammonia silver staining, Masson's trichrome staining and TEM observation. Results revealed that polyurethane nerve guide scaffolds exhibit much better regeneration behavior than PCL, silicone tube groups and comparable to autograft. Electrophysiological recovery was also seen in 36percent, 76percent, and 87percent of rats in the PCL, PUCL-ran-EG, and autograft groups respectively, whilst 29.8percent was observed in the silicone tube groups. Biodegradation in vitro and in vivo show proper degradation of the PUCL-ran-EG nerve guide scaffolds. This study has demonstrated that without further modification, plain PUCL-ran-EG nerve guide scaffolds can help peripheral nerve regeneration excellently. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
BLOCK POLYURETHANES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
POLY( 3-CAPROLACTONE) |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
POLY(ETHYLENE GLYCOL) |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
NERVE GUIDE SCAFFOLD |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PERIPHERAL NERVE REGENERATION |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Niu, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chen, K. C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
He, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Yu, W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Huang, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Xu, K. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1fiiTXC7B9gBEfE1sBPDWr4IFdK99YLYQ/view?usp=drivesdk">https://drive.google.com/file/d/1fiiTXC7B9gBEfE1sBPDWr4IFdK99YLYQ/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
