Scaffolds from alternating block polyurethanes of poly (?-caprolactone)and poly (ethylene glycol)with stimulation and guidance of nerve growth and better nerve repair than autograft. (Record no. 52640)
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| 000 -LEADER | |
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| fixed length control field | 02498nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625162413.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-18490 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Scaffolds from alternating block polyurethanes of poly (?-caprolactone)and poly (ethylene glycol)with stimulation and guidance of nerve growth and better nerve repair than autograft. |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Journal of biomedical Materials Research Part A, 103(7), p.2355-2364, 2015 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Nerve repair scaffolds from novel alternating block polyurethanes (PUCL-alt-PEG)based on PCL and PEG without additional growth factors or proteins were prepared by a particle leaching method. The scaffolds have pore size 10-20 µm and porosity 92percent. Mechanical tests showed that the polyurethane scaffolds have maximum loads of 5.97 ± 0.35 N and maximal stresses of 8.84 ± 0.5 MPa. Histocompatiblity of the nerve repair scaffolds was tested in a SD rat model for peripheral nerve defect treatment. Two types of treatments including PUCL-alt-PEG scaffolds and autografts were compared in rat model. After 32 weeks, bridging of a 12 mm defect gap by the regenerated nerve was observed in all rats. The nerve regeneration was systematically characterized by sciatic function index (SFI), electrophysiology, histological assessment including HE staining, immunohistochemistry, ammonia sliver staining, Masson's trichrome staining and TEM observation. Results revealed that nerve repair scaffolds from PUCL-alt-PEG exhibit better regeneration effects compared to autografts. Electrophysiological recovery was seen in 90percent and 87percent of rats in PUCL-alt-PEG and autograft groups respectively. Biodegradation in vitro and in vivo shows good degradation match of PUCL-alt-PEG scaffolds with nerve regeneration. It demonstrates that plain nerve repair scaffolds from PUCL-alt-PEG biomaterials can achieve peripheral nerve regeneration satisfactorily |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ALTERNATING BLOCK POLYURETHANES, POLY(E-CAPROLAC-TONE)(PCL) |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | POLY(ETHYLENE GLYCOL)(PEG) |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | SCAFFOLD, PERIPHERY NERVE REPAIR |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Niu, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, K. C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liu, X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ye, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xu, K. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/19SuTIupvstmejoV-WjgRfOrtiiPyQ-pq/view?usp=drivesdk">https://drive.google.com/file/d/19SuTIupvstmejoV-WjgRfOrtiiPyQ-pq/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-18490 | 25.06.2025 | 25.06.2025 | Documentos solicitados |