Modulating protein-protein interaction networks in protein homeostasis. (Record no. 52664)
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| fixed length control field | 01811nam a2200241Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625162413.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-18514 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Modulating protein-protein interaction networks in protein homeostasis. |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Current Opinion in Chemical Biology,, 50, p.55-65, 2019 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Protein-protein interactions (PPIs)occur in complex networks. These networks are highly dependent on cellular context and can be extensively altered in disease states such as cancer and viral infection. In recent years, there has been significant progress in developing inhibitors that target individual PPIs either orthosterically (at the interface)or allosterically. These molecules can now be used as tools to dissect PPI networks. Here, we review recent examples that highlight the use of small molecules and engineered proteins to probe PPIs within the complex networks that regulate protein homeostasis. Researchers have discovered multiple mechanisms to modulate PPIs involved in host/viral interactions, deubiquitinases, the ATPase p97/VCP, and HSP70 chaperones. However, few studies have evaluated the effect of such modulators on the target's network or have compared the biological implications of different modulation strategies. Such studies will have an important impact on next generation therapeutics. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PROTEIN-PROTEIN INTERACTIONS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PROTEIN HOMEOSTASIS |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhong, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lee, G. M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sijbesma, E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ottmann, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Arkin, M. R |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/18wqC8J0diH45L4LPjlLsdCE18AwMYvrl/view?usp=drivesdk">https://drive.google.com/file/d/18wqC8J0diH45L4LPjlLsdCE18AwMYvrl/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-18514 | 25.06.2025 | 25.06.2025 | Documentos solicitados |