Synthesis and characterization of metformin-pluronic based polyurethanes for controlled drug delivery (Record no. 52683)

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control field MX-MdCICY
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control field 20250625162414.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-18533
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Title Synthesis and characterization of metformin-pluronic based polyurethanes for controlled drug delivery
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Volume/sequential designation International Journal of Polymeric Materials and Polymeric BioMaterials, p.1-12., 2020
520 3# - SUMMARY, ETC.
Summary, etc. Segmented polyurethanes (SPU)were synthesized with Pluronic F127 (PLU)as soft segment and 4,4?-methylene-bis(cyclohexyl)diisocyanate (HMDI)and Metformin (Met)as rigid segment (HMDI-Met)while antidiabetic content increased by using 20percet, 30percent, 40percent, and 50percent of rigid segments. The Met incorporation was provided by FTIR, Raman, NMR, and XPS. By increasing the content of rigid segments, the first decomposition temperature tends to increase from 317?°C to 361?°C while Tg was modified from ?80?°C to ?50?°C. Mass loss was observed during accelerated degradation and therefore SPU-PLU-Met can deliver up to 40?µg/30?days of Met. Cytotoxicity test showed no deleterious effect.
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Topical term or geographic name entry element SEGMENTED
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element POLYURETHANE
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Topical term or geographic name entry element METFORMIN
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Topical term or geographic name entry element BIOCOMPATIBILITY
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Bonilla-Hernández, M.
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Personal name Zapata-Catzin, G. A.
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Personal name Castillo-Cruz, O. D. J.
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Personal name Vargas-Coronado, R. F.
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Personal name Cervantes-Uc, J. M.
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Personal name Xool-Tamayo, J. F.
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Personal name Cauich-Rodríguez, J. V.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1awBGsMCWNgNGsmWIx9eOsF4aPu1NWIIB/view?usp=drivesdk">https://drive.google.com/file/d/1awBGsMCWNgNGsmWIx9eOsF4aPu1NWIIB/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-18533 25.06.2025 25.06.2025 Documentos solicitados