MARC details
| 000 -LEADER |
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| fixed length control field |
02365nam a2200289Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625162415.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-18587 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Metabolic profiling and in vivo hepatoprotective activity of Malpighia glabra L. leaves. |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Journal of Food BioChemistry, 45(2), p.e13588, 2021 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Although Malpighia glabra Linn. fruits are well studied for their nutritional and medicinal prominence; little attention has been given to the leaves. Our study intends to investigate the leaves metabolic profile using Q?TOF LC/MS/MS (Quadrupole?Time?of?Flight?Liquid?Chromatography?Mass?Spectrometry), and to explore their in vivo hepatoprotective activity in rats using CCL4?induced hepatic damage model and silymarin as standard. Fifty metabolites were characterized, belonging to different classes; coumarins (capensine, daphnoretin, and scopoletin), flavonoids (mainly quercetin and apigenin glycosides), phenolic acids (cinnamic acid and quinic acid derivatives)and amino acids (adenosine, homoisoleucine, and phenylalanine).These compounds are detected in the leaves for the first time. The hepatoprotective activity at three doses (200, 400, and 800 mg/kg)was investigated. The dose of 800 mg/Kg showed the highest hepatoprotective effect as it reduced the elevated serum levels of ALT, AST, NO, and TNF?? liver content by 26, 24, 23, and 42percent, respectively, it also remarkably increased the serum level of catalase by 102percent. All the tested doses showed higher reduction in serum level of TNF?? compared to silymarin which suggests their strong anti?inflammatory potential. M. glabra leaves are revealed to be a rich source of secondary metabolites and proved to possess significant hepatoprotective potential. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ACEROLA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
FLAVONOIDS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
HEPATOPROTECTIVE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MALPIGHIA GLABRA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PHENOLIC ACIDS FLAVONOIDS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Q-TOF LC/MS/MS |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
El-Hawary, S. S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
El-Fitiany, R. A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Mousa, O. M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Salama, A. A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
El Gedaily, R. A |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1ojRitBnxIBcI3NAoKqDEUmaSjYTf9lyC/view?usp=drivesdk">https://drive.google.com/file/d/1ojRitBnxIBcI3NAoKqDEUmaSjYTf9lyC/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
