Down-regulation of the E2 subunit of 2-oxoglutarate dehydrogenase modulates plant growth by impacting carbon-nitrogen metabolism in Arabidopsis thaliana. (Record no. 52790)

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fixed length control field 02291nam a2200289Ia 4500
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control field MX-MdCICY
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control field 20250625162416.0
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Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-18644
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245 10 - TITLE STATEMENT
Title Down-regulation of the E2 subunit of 2-oxoglutarate dehydrogenase modulates plant growth by impacting carbon-nitrogen metabolism in Arabidopsis thaliana.
490 0# - SERIES STATEMENT
Volume/sequential designation Plant & Cell Physiology, https://doi.org/10.1093/pcp/pcab036, 2021
520 3# - SUMMARY, ETC.
Summary, etc. In Arabidopsis thaliana, two genes encode the E2 subunit of the 2-oxoglutarate dehydrogenase (2-OGDH), a multimeric complex composed of three subunits. To functionally characterize the isoforms of E2 subunit, we isolated Arabidopsis mutant lines for each gene encoding the E2 subunit and performed a detailed molecular and physiological characterization of the plants under controlled growth conditions. The functional lack of expression of E2 subunit isoforms of 2-OGDH increased plant growth, reduced dark respiration, and altered carbohydrate metabolism without changes in the photosynthetic rate. Interestingly, plants from e2-ogdh lines also exhibited reduced seed weight without alterations in total seed number. We additionally observed that downregulation of 2-OGDH activity led to minor changes in the levels of tricarboxylic acid (TCA)cycle intermediates without clear correlation with the reduced expression of specific E2-OGDH isoforms. Furthermore, the e2-ogdh mutant lines exhibited a reduction by up to 25 percent in the leaf total amino acids without consistent changes in the amino acid profile. Taken together, our results indicate that the two isoforms of E2 subunit play a similar role in carbon-nitrogen metabolism, in plant growth and in seed weight.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PRIMARY METABOLISM
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element 2-OGDH
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element RESPIRATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element TCA CYCLE
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Condori-Apfata, J. A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Batista-Silva, W.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Medeiros, D. B.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Rafael Vargas, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Valente, L. M. L.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Luis Perez Diaz, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Nunes-Nesi, A.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1WZDG1feie7irQ1bO8NuIrD7BO_GKmYdF/view?usp=drivesdk">https://drive.google.com/file/d/1WZDG1feie7irQ1bO8NuIrD7BO_GKmYdF/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-18644 25.06.2025 25.06.2025 Documentos solicitados