MARC details
| 000 -LEADER |
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| fixed length control field |
02212nam a2200289Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625162418.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-18733 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Medicinal species as MTDLs: Turnera diffusaWilld. Ex Schult inhibits CNS-enzymes and delays glutamate excitotoxicity in SH-SY5Y cells viaoxidative damage |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Food and Chemical Toxicology, 106, p.466-476, 2017 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Tne of the most promising approaches to confront the complexity of central nervous system disorders are new multi-target directed ligands (MTDLs). Five medicinal species (Cereus grandiflorus (L.)Mill., Hyssopus officinalis L., Acorus calamus L., Silybum marianum L. Gaertn. and Turnera diffusa Willd. Ex Schult), selected for their ethnopharmacological relevance, were object for in vitroscreening. The aqueous extract of T. diffusa revealed the strongest neuroactive potential, inhibiting monoamine oxidase-A (IC 50 = 129.80 ± 11.97 µg/mL), and acetyl- and butyrylcholinesterase (IC 25 = 0.352 ± 0.011 and 0.370 ± 0.036 mg/mL, respectively). Its phenolic profile was established for the first time by HPLC-DAD-ESI/MSn. Twenty-six out of thirty-seven compounds were newly identified in this species. The pre-treatment with this flavonoidrich extract promoted a rightward shift of the glutamate concentration-neuronal cell (SH-SY5Y)death response curve. Furthermore, it significantly reduced the early phase formation of intracellular reactive species after glutamate and t-BHP exposure, suggesting that neuroprotection in SH-SY5Y cells was, in part, mediated by antioxidant mechanisms. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MEDICINAL SPECIES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TURNERA DIFFUSA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
FLAVONOIDS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
NEUROPROTECTION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CNS ENZYMES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
GLUTAMATE EXCITOTOXICITY |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Bernardo, João |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Ferreres, Federico |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Gil-Izquierdo, Ángel |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Valentão, Patrícia |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Andrade, Paula B. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1AmK11mr07ZvBThs70IZPuaItaYqJ21Hz/view?usp=drivesdk">https://drive.google.com/file/d/1AmK11mr07ZvBThs70IZPuaItaYqJ21Hz/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
