The origin of genomic N 6-methyl-deoxyadenosine in mammalian cells. (Record no. 52963)

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control field MX-MdCICY
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control field 20250625162419.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-18817
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Title The origin of genomic N 6-methyl-deoxyadenosine in mammalian cells.
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Volume/sequential designation Nature Chemical Biology, 16(6), p.630-634, 2020
520 3# - SUMMARY, ETC.
Summary, etc. The proposal that N6-methyl-deoxyadenosine (m6dA)acts as an epigenetic mark in mammals remains controversial. Using isotopic labeling coupled to ultrasensitive mass spectrometry, we confirm the presence of low-level m6dA in mammalian DNA. However, the bulk of genomic m6dA originates from ribo-N6-methyladenosine, which is processed via the nucleotide-salvage pathway and misincorporated by DNA polymerases. Our results argue against m6dA acting as a heritable, epigenetic DNA mark in mammalian cells.
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Personal name Musheev, M. U.
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Personal name Baumgärtner, A.
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Personal name Krebs, L.
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Personal name Niehrs, C.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1iS-MxnhZqutIsVt8Y2XVhJe8bPuv38ys/view?usp=drivesdk">https://drive.google.com/file/d/1iS-MxnhZqutIsVt8Y2XVhJe8bPuv38ys/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-18817 25.06.2025 25.06.2025 Documentos solicitados