Novel non-cytotoxic, bioactive and biodegradable hybrid materials based on polyurethanes/TiO2 for biomedical applications. (Record no. 52977)

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control field MX-MdCICY
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control field 20250625162419.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-18833
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Title Novel non-cytotoxic, bioactive and biodegradable hybrid materials based on polyurethanes/TiO2 for biomedical applications.
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Volume/sequential designation Materials Science and Engineering: C, 75, p.375-384, 2017
520 3# - SUMMARY, ETC.
Summary, etc. Titanium compounds have demonstrated great interfacial properties with biological tissues whereas a wide variety of polyurethanes have also been successfully probed in medical applications. However, studies about hybrids based on polyurethanes/TiO for medical applications are scarce. The aim of this work is to design novel biodegradable hybrid materials based on polyurethanes/TiO (80percent organic-20percent inorganic)and to perform a preliminary study of the potential applications in bone regeneration. The hybrids have been prepared by a sol-gel reaction using titanium isopropoxide as precursor of the inorganic component and polyurethane as the organic one. A series of polyurethanes has been prepared using different polyesters glycol succinate as soft segment, and 1,6-diisocyanatohexane (HDI)and butanediol (BD)as linear hard segment. The spectroscopy techniques used allow to confirm the formation of the required polyurethanes by the identification of bands related to carboxylic groups (-COOH), and the amine groups (-NH-), and also the Ti-OH bonds and the bonds related to the interconnected network between the inorganic and the organic components from hybrids. The results from SEM/EDS show a homogeneous distribution of the inorganic component into the organic matrix. The nontoxic character of the hybrid (H400)was probed using MG-63 cell line with over 90percent of cell viability. Finally, the formation of a hydroxyapatite layer in the material surface after 21 days of soaking in SBF shows the bioactive character.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name González-García, D. M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Jurado, L. T.
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Personal name Jiménez-Gallegos, R.
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Personal name Rodríguez-Lorenzo, L. M.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1vhu39y8NxxYOgMmN2s6G7ouqq1gzRHSM/view?usp=drivesdk">https://drive.google.com/file/d/1vhu39y8NxxYOgMmN2s6G7ouqq1gzRHSM/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-18833 25.06.2025 25.06.2025 Documentos solicitados