MARC details
| 000 -LEADER |
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| fixed length control field |
01935nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625162422.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-18947 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Steroidal saponins and sapogenins from fenugreek and their inhibitory activity against á-glucosidase |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Steroids, 161, p.108690, 2020 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
The seed of Trigonella foenum-graecum L. (fenugreek)has been reported to be rich in saponins, especially the dioscin or diosgenin, which are natural anti-diabetic agents with relatively low toxicity. Thus, the present study was to purify the saponins and sapogenins from fenugreek and to evaluate their ?-glucosidase inhibitory activity in vitro. As a result, 33 steroidal saponins and sapogenins were isolated, including six undescribed ones and 27 previously known molecules. Among them, compounds 10, 12, 17, 22 and 29 were five 25R and 25S isomer mixtures of spirostanol saponins or sapogenins. The structures of compound 1-6 were established by 1D and 2D NMR spectroscopic analyses, high-resolution mass spectrometry, and chemical evidence. Compared to the positive control, sapogenins 26, 27, 14 and saponins 18 and 23 considerably inhibited ?-glucosidase at IC50 values of 15.16, 8.98, 7.26, 5.49 and 14.01 ?M, respectively. These results support the therapeutic potential of fenugreek in the treatment of diabetes with saponins and sapogenins as the active constituents. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
FENUGREEK |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
STEROIDAL SAPONINS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
STEROIDAL SAPOGENINS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ALFA-GLUCOSIDASE |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zhang, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Xu, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wang, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Xia, X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dai, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Zhao, Y. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1cSySskDngyS1l-rExwJLkk5lFqYNtjGy/view?usp=drivesdk">https://drive.google.com/file/d/1cSySskDngyS1l-rExwJLkk5lFqYNtjGy/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
