Cordyceps Improves Obesity and its Related Inflammation via Modulation of Enterococcus cecorum Abundance and Bile Acid Metabolism (Record no. 53170)

MARC details
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fixed length control field 02191nam a2200301Ia 4500
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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625162423.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-19029
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245 10 - TITLE STATEMENT
Title Cordyceps Improves Obesity and its Related Inflammation via Modulation of Enterococcus cecorum Abundance and Bile Acid Metabolism
490 0# - SERIES STATEMENT
Volume/sequential designation The American Journal of Chinese Medicine, 50(3), p.1-22, 2022
520 3# - SUMMARY, ETC.
Summary, etc. Dysbiotic gut microbiota has been identified as a primary mediator of inherent inflammation that underlies the pathogenesis of obesity. Cordyceps comprises the larval body and the stroma of Cordyceps sinensis (BerK.)Sacc. parasiting on Hepialidae larvae of moths (H. pialusoberthur)with potent metabolic regulation functions. The underlying anti-obesity mechanisms, however, remain largely unknown. Here, we demonstrate that the water extract of Cordyceps attenuates glucose and lipid metabolism disorders and its associated inflammation in high-fat diet (HFD)-fed mice. 16S rRNA gene sequencing and microbiomic analysis showed that Cordyceps reduced the amounts of Enterococcus cecorum, a bile-salt hydrolase-producing microbe to regulate the metabolism of bile acids in the gut. Importantly, E. cecorum transplantation or liver-specific knockdown of farnesoid X receptor (FXR), a bile acid receptor, diminished the protective effect of Cordyceps against HFD-induced obesity. Together, our results shed light on the mechanisms that underlie the glucose- and lipid-lowering effects of Cordyceps and suggest that targeting intestinal E. cecorum or hepatic FXR are potential anti-obesity and anti-inflammation therapeutic avenues.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BILE ACIDS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CORDYCEPS SINENSIS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ENTEROCOCCUS CECORUM
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element FXR
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element OBESITY
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wu, G. D.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Pan, A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Zhang, X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Cai, Y. Y.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wang, Q.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Huang, F. Q.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Liu, Q.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1br0w5Gl62DsjZdXpkhbD0mqI6cCdPWRO/view?usp=drivesdk">https://drive.google.com/file/d/1br0w5Gl62DsjZdXpkhbD0mqI6cCdPWRO/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-19029 25.06.2025 25.06.2025 Documentos solicitados