Alendronate crosslinked chitosan/polycaprolactone scaffold for bone defects repairing (Record no. 53260)

MARC details
000 -LEADER
fixed length control field 02367nam a2200277Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625162425.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-19121
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
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245 10 - TITLE STATEMENT
Title Alendronate crosslinked chitosan/polycaprolactone scaffold for bone defects repairing
490 0# - SERIES STATEMENT
Volume/sequential designation International Journal of Biological Macromolecules, 204, p.441-456, 2022
520 3# - SUMMARY, ETC.
Summary, etc. Here, we evaluated osteogenic differentiation in vitro and new bone formation in vivo using an alendronate-loaded chitosan/polycaprolactone scaffold (CS/PCL)in rats with a critical-sized calvarial defect. Through the action of genipin, which has a crosslinking function, alendronate (AL)was anchored throughout the CS/PCL composite scaffold (CS/PCL@AL)to form an AL sustained release system. We demonstrated that CS/PCL@AL scaffolds significantly enhanced the osteogenic differentiation of ectomesenchymal stem cells (EMSCs)in vitro. Additionally, we explored the possible molecular mechanism of CS/PCL@AL scaffolds in the osteogenic differentiation of EMSCs. This composite scaffold exerted two positive effects on EMSC osteogenic differentiation: 1)the CS/PCL@AL scaffold enhanced EMSC osteogenic differentiation by upregulating bone morphogenetic protein 2, interleukin 10 and laminin expression; and 2)the CS/PCL@AL scaffold promoted the osteogenic differentiation of EMSCs by activating the yes-associated protein (YAP)signaling pathway. YAP and its downstream target transglutaminase are crucial mediators in the osteogenic differentiation of EMSCs. Finally, micro-computed tomography analyses and histology results suggested that the CS/PCL@AL scaffold exhibited a superior capacity to accelerate new and mature bone formation in skull bone defects in Sprague-Dawley rats. This simple and low-cost technology may represent a promising strategy to construct an efficient delivery system to repair bone defects.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CHITOSAN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ALENDRONATE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PCL
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Shi, W.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Zhang, X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Bian, L.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Dai, Y.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wang, Z.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Zhou, Y.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Lu, X.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1FP4nyZIckkMpLkP4rxq0Ptpr3BUXR90z/view?usp=drivesdk">https://drive.google.com/file/d/1FP4nyZIckkMpLkP4rxq0Ptpr3BUXR90z/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-19121 25.06.2025 25.06.2025 Documentos solicitados