Syntheses, structural characterization and evaluation of the anti-tubercular activity of copper (II)complexes containing 3-methoxysalicylaldehyde-4-methylthiosemicarbazone (Record no. 53331)

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fixed length control field 02024nam a2200313Ia 4500
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control field MX-MdCICY
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control field 20250625162426.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-19193
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Title Syntheses, structural characterization and evaluation of the anti-tubercular activity of copper (II)complexes containing 3-methoxysalicylaldehyde-4-methylthiosemicarbazone
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Volume/sequential designation Journal of Molecular Structure, 1257, p.132589, 2022
520 3# - SUMMARY, ETC.
Summary, etc. In the present work three novel copper (II)complexes ([CuL(CH3COO)] (1), [CuL(phen)] (2)and [CuL(bpy)] (3)(where phen=1,10-phenanthroline; bpy=2,2? bipyridyl)) containing 3-methoxysalicylaldehyde-4-methylthiosemicarbazone (HL)were synthesised and characterised. All the complexes were characterized using spectral techniques like FT-IR, ESI-MS, TGA-DTA, UV-Vis, ESR and VSM. The structure of complex 2 was confirmed by single-crystal X-ray structure determination. Complex 2 crystallized in a monoclinic crystal system and P 21/n space group with a distorted square pyramidal geometry. In vitro anti-TB and cytotoxicity studies were also carried out using MABA (Microplate Alamar Blue Assay)and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide)assay respectively. All the copper (II)complexes have shown excellent anti-TB properties in the nano-molar concentration range and exhibit low cytotoxicity.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element COPPER COMPLEX
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element THIOSEMICARBAZONE
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Topical term or geographic name entry element SINGLE-CRYSTAL X-RAY DIFFRACTION
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Topical term or geographic name entry element MYCOBACTERIUM TUBERCULOSIS H37RV
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Topical term or geographic name entry element INHIBITION
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Topical term or geographic name entry element CYTOTOXICITY
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Topical term or geographic name entry element SELECTIVITY INDEX
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Personal name Hegde, P. L.
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Personal name Bhat, S. S.
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Personal name Revankar, V. K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Shaikh, S. A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kumara, K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Lokanath, N. K.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1M3l0o1eV5cvEWfAmxFfdVIEVMKPw3x7d/view?usp=drivesdk">https://drive.google.com/file/d/1M3l0o1eV5cvEWfAmxFfdVIEVMKPw3x7d/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-19193 25.06.2025 25.06.2025 Documentos solicitados