MARC details
| 000 -LEADER |
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| fixed length control field |
02562nam a2200289Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625162430.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-19399 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Mechanochemical synthesis of six Cu(II)complexes with selected thiols, their physicochemical characterization and interaction with DNA |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Journal of Molecular Structure, 1265, p.133436, 2022 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Cysteine together with histidine (His2Cys)has been identified as one of the ligands in Type 1 copper protein active sites, and Cu-S(Cys)interaction determines their unique spectroscopic features. This work reports the synthesis of model Cu(II)-thiolates, which could mimic the Type 1 sites. The Cu (II)-complexes with l-cysteine, n-acetylcysteine, l-glutathione, l-penicillamine, mercaptosuccinic acid and dl-dithiothreitol were synthesized by solvent-free mechanochemical methods. The complexes were found to be of the ML2 type as revealed by solid-state analytical techniques including FT-IR (ATR)spectroscopy, Raman spectroscopy, electronic absorption spectroscopy (diffuse reflectance), powder X-ray diffraction and desorption electrospray ionization mass spectrometry. These compounds are difficult, in some cases impossible, to isolate from solution because of rapid oxidation of thiols to disulfides and reduction of Cu(II)to Cu(I)or Cu(0). However, in the solid state these complexes were found to be highly stable and exhibited spectroscopic features similar to those in the Type 1 site. Interaction of the complexes with genomic DNA isolated from human blood was studied by electrophoresis, which showed that Cu(II)-mercaptosuccinic acid and Cu(II)-n-acetylcysteine caused extensive degradation, whereas Cu(II)-penicillamine amd Cu(II)-glutathione significantly degraded the DNA. Cu(II)-cysteine appears to form DNA adducts. Docking of Cu(II)-cysteine with thioredoxine reductase suggests that the complex has the potential to inhibit the activity of the enzyme. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CU(II)COMPLEXES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MECHANOCHEMICAL SYNTHESIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TYPE 1 COPPER PROTEINS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
DRUG-DNA INTERACTION |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kazimi, S. G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Iqbal, M. S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Mulligan, C. C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Baseer, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Rehman, A. U. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Farooqi, F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Person, J. R |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1voRRqi1usxcr2dAehRi5nwPpq9bY35eF/view?usp=drivesdk">https://drive.google.com/file/d/1voRRqi1usxcr2dAehRi5nwPpq9bY35eF/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
