Chemical inhibition of the auxin inactivation pathway uncovers the roles of metabolic turnover in auxin homeostasis (Record no. 53593)
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| 000 -LEADER | |
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| fixed length control field | 01809nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625162431.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-19467 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Chemical inhibition of the auxin inactivation pathway uncovers the roles of metabolic turnover in auxin homeostasis |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Proceedings of the National Academy of Sciences, 119(32), p.e2206869119, 2022 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The phytohormone auxin, indole-3-acetic acid (IAA), plays a prominent role in plant development. Auxin homeostasis is coordinately regulated by auxin synthesis, transport, and inactivation; however, the physiological contribution of auxin inactivation to auxin homeostasis has not been determined. The GH3 IAA-amino acid conjugating enzymes play a central role in auxin inactivation. Chemical inhibition of GH3 proteins in planta is challenging because the inhibition of these enzymes leads to IAA overaccumulation that rapidly induces GH3 expression. Here, we report the characterization of a potent GH3 inhibitor, kakeimide, that selectively targets IAA-conjugating GH3 proteins. Chemical knockdown of the auxin inactivation pathway demonstrates that auxin turnover is very rapid (about 10 min)and indicates that both auxin biosynthesis and inactivation dynamically regulate auxin homeostasis. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | AUXIN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PLANT HORMONE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CHEMICAL BIOLOGY |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fukui, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Arai, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tanaka, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aoi, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kukshal, V. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jez, J. M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hayashi, K. I. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1Q_JrwbF6d5FPbZbko09oPDS5dQdJuxZ1/view?usp=drivesdk">https://drive.google.com/file/d/1Q_JrwbF6d5FPbZbko09oPDS5dQdJuxZ1/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-19467 | 25.06.2025 | 25.06.2025 | Documentos solicitados |