Indole-3-pyruvic acid regulates TAA1 activity, which plays a key role in coordinating the two steps of auxin biosynthesis (Record no. 53647)
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| fixed length control field | 02387nam a2200289Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625162432.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-19522 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Indole-3-pyruvic acid regulates TAA1 activity, which plays a key role in coordinating the two steps of auxin biosynthesis |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Proceedings of the National Academy of Sciences, 119(25), p.e2203633119, 2022 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Auxin biosynthesis involves two types of enzymes: the Trp aminotransferases (TAA/TARs)and the flavin monooxygenases (YUCCAs). This two-step pathway is highly conserved throughout the plant kingdom and is essential for almost all of the major developmental processes. Despite their importance, it is unclear how these enzymes are regulated and how their activities are coordinated. Here, we show that TAA1/TARs are regulated by their product indole-3-pyruvic acid (IPyA)(or its mimic KOK2099)via negative feedback regulation in Arabidopsis thaliana. This regulatory system also functions in rice and tomato. This negative feedback regulation appears to be achieved by both the reversibility of Trp aminotransferase activity and the competitive inhibition of TAA1 activity by IPyA. The Km value of IPyA is 0.7 µM, and that of Trp is 43.6 µM; this allows IPyA to be maintained at low levels and prevents unfavorable nonenzymatic indole-3-acetic acid (IAA)formation from IPyA in vivo. Thus, IPyA levels are maintained by the push (by TAA1/TARs)and pull (by YUCCAs)of the two biosynthetic enzymes, in which TAA1 plays a key role in preventing the over- or under-accumulation of IPyA. TAA1 prefer Ala among various amino acid substrates in the reverse reaction of auxin biosynthesis, allowing TAA1 to show specificity for converting Trp and pyruvate to IPyA and Ala, and the reverse reaction. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | TRP AMINOTRANSFERASE OF ARABIDOPSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | AUXIN BIOSYNTHESIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CHEMICAL BIOLOGY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | FEEDBACK REGULATION |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sato, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Soeno, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kikuchi, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Narukawa-Nara, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yamazaki, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kakei, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shimada, Y. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1D0OaLxD3jjKMY_duE4l7DU3irPoeudyA/view?usp=drivesdk">https://drive.google.com/file/d/1D0OaLxD3jjKMY_duE4l7DU3irPoeudyA/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-19522 | 25.06.2025 | 25.06.2025 | Documentos solicitados |