Barley stripe mosaic virus cb protein targets thioredoxin h-type 1 to dampen salicylic acidmediated defenses (Record no. 53790)

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fixed length control field 02210nam a2200241Ia 4500
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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625162435.0
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Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-19667
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Title Barley stripe mosaic virus cb protein targets thioredoxin h-type 1 to dampen salicylic acidmediated defenses
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Volume/sequential designation Plant Physiology, 189, p.1715-1727, 2022
520 3# - SUMMARY, ETC.
Summary, etc. Salicylic acid (SA)acts as a signaling molecule to perceive and defend against pathogen infections. Accordingly, pathogens evolve versatile strategies to disrupt the SA-mediated signal transduction, and how plant viruses manipulate the SA-dependent defense responses requires further characterization. Here, we show that barley stripe mosaic virus (BSMV)infection activates the SA-mediated defense signaling pathway and upregulates the expression of Nicotiana benthamiana thioredoxin h-type 1 (NbTRXh1). The ?b protein interacts directly with NbTRXh1 in vivo and in vitro. The overexpression of NbTRXh1, but not a reductase-defective mutant, impedes BSMV infection, whereas low NbTRXh1 expression level results in increased viral accumulation. Similar with its orthologs in Arabidopsis (Arabidopsis thaliana), NbTRXh1 also plays an essential role in SA signaling transduction in N. benthamiana. To counteract NbTRXh1-mediated defenses, the BSMV ?b protein targets NbTRXh1 to dampen its reductase activity, thereby impairing downstream SA defense gene expression to optimize viral cell-to-cell movement. We also found that NbTRXh1-mediated resistance defends against lychnis ringspot virus, beet black scorch virus, and beet necrotic yellow vein virus. Taken together, our results reveal a role for the multifunctional ?b protein in counteracting plant defense responses and an expanded broad-spectrum antibiotic role of the SA signaling pathway.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Jiang, Z.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Jin, X.
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Personal name Yang, M.
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Personal name Pi, Q.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Cao, Q.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Li, Z.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Li, D.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/18C2nttJvWoxmBtCe8ZhCLty8bn8RgaVc/view?usp=drivesdk">https://drive.google.com/file/d/18C2nttJvWoxmBtCe8ZhCLty8bn8RgaVc/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-19667 25.06.2025 25.06.2025 Documentos solicitados