MARC details
| 000 -LEADER |
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| fixed length control field |
02864nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625162435.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-19686 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Chemometrics-enhanced high-performance liquid chromatography-diode array detection strategy to quantify protob erb erine alkaloids in varying Coptidis Rhizoma-related medicines |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Journal of Chromatography A, 1681, p.463426, 2022 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Quantitation of protoberberine alkaloids is an essential guarantee for efficacy control and medication safety of Coptidis Rhizoma (CR)related medicines. Traditional univariate chromatography faced challenges with co-elution, unknown interferences, and retention time shift when analyzing isomeric analytes in varying sample matrices. We presented a chemometrics-enhanced high-performance liquid chromatography-diode array detection (HPLC-DAD)strategy for simultaneous quantification of six protoberberine alkaloids and processed multi-channels chromatographic-spectral data with four second-order calibration algorithms. Chromatographic conditions were firstly optimized. Four groups of predicted samples were modeled individually with the designed calibration set. Mathematical resolutions were then obtained, and pseudo-univariate regression gave the quantitative concentration of each analyte. Four models were scored on fit, linearity, recovery, and robustness, where alternating trilinear decomposition assisted multivariate curve resolution (ATLD-MCR)exhibited an optimal and stable performance. Besides, the resolved spectra presented high consistency with the actual spectra (r?0.9993). Limits of quantification (LOQ)fully met the pharmacopoeia stipulation and were 0.17, 0.60, 0.19, 0.74, 0.15, and 0.38 µg mL-1 for columbamine, epiberberine, jatrorrhizine, coptisine, palmatine, and berberine, respectively. The importance of this strategy is to exploit collinearity resolution and additional selectivity that permit accurate quantitation at poor chromatographic resolutions, avoiding individual pretreatment and HPLC optimizations for different samples. This study provides a universal alternative for routine quality assessment of protoberberine alkaloids in CR-related medicines. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
COPTIDIS RHIZOMA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MATHEMATICAL SEPARATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PROTOBERBERINE ALKALOIDS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
SECOND-ORDER CALIBRATION |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chen, A. Q. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wu, H. L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sun, H. B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wang, X. Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Yan, X. Q. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wang, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Yu, R. Q. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1Oj27wZqO1JdwByzLN1jzfUeNpNw_QPaS/view?usp=drivesdk">https://drive.google.com/file/d/1Oj27wZqO1JdwByzLN1jzfUeNpNw_QPaS/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
