Current and future approaches for in vitro hit discovery in diabetes mellitus (Record no. 53885)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 01728nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625162436.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-19766 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Current and future approaches for in vitro hit discovery in diabetes mellitus |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Drug Discovery Today, 27(10), p.1-13, 2022 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Type 2 diabetes mellitus (T2DM)is a serious public health problem. In this review, we discuss current and promising future drugs, targets, in vitro assays and emerging omics technologies in T2DM. Importantly, we open the perspective to image-based high-content screening (HCS), with the focus of combining it with metabolomics or lipidomics. HCS has become a strong technology in phenotypic screens because it allows comprehensive screening for the cell-modulatory activity of small molecules. Metabolomics and lipidomics screen for perturbations at the molecular level. The combination of these data-intensive comprehensive technologies is enabled by the rapid development of artificial intelligence. It promises a deep cellular and molecular phenotyping directly linked to chemical information about the applied drug candidates or complex mixtures. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CELL PAINTING |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | HIGH-CONTENT SCREENING |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | FUNCTIONAL METABOLOMICS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | LIPIDOMICS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | BIOACTIVES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | DRUG DISCOVERY |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xin, Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kupczyk, E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schmitt-Kopplin, P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mueller, C. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1DvQKgenv40Me4xvpxT3xzZv8PAlFpeUu/view?usp=drivesdk">https://drive.google.com/file/d/1DvQKgenv40Me4xvpxT3xzZv8PAlFpeUu/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-19766 | 25.06.2025 | 25.06.2025 | Documentos solicitados |