PHLPPs: Emerging players in metabolic disorders (Record no. 53892)

MARC details
000 -LEADER
fixed length control field 01937nam a2200301Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625162436.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-19773
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245 10 - TITLE STATEMENT
Title PHLPPs: Emerging players in metabolic disorders
490 0# - SERIES STATEMENT
Volume/sequential designation Drug Discovery Today, 27(10), p.1-11, 2022
520 3# - SUMMARY, ETC.
Summary, etc. That reversible protein phosphorylation by kinases and phosphatases occurs in metabolic disorders is well known. Various studies have revealed that a multi-faceted and tightly regulated phosphatase, pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP)-1/2 displays robust effects in cardioprotection, ischaemia/reperfusion (I/R), and vascular remodelling. PHLPP1 promotes foamy macrophage development through ChREBP/AMPK-dependent pathways. Adipocyte-specific loss of PHLPP2 reduces adiposity, improves glucose tolerance,and attenuates fatty liver via the PHLPP2-HSL-PPAR? axis. Discoveries of PHLPP1-mediated insulin resistance and pancreatic ? cell death via the PHLPP1/2-Mst1-mTORC1 triangular loop have shed light on its significance in diabetology. PHLPP1 downregulation attenuates diabetic cardiomyopathy (DCM)by restoring PI3K-Akt-mTOR signalling. In this review, we summarise the functional role of, and cellular signalling mediated by, PHLPPs in metabolic tissues and discuss their potential as therapeutic targets.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PHLPP1
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PHLPP2
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element TYPE 2 DIABETES
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CARDIOVASCULAR DYSFUNCTION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ATHEROSCLEROSIS
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Balamurugan, K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Chandra, K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Latha, S. S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Swathi, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Joshi, M. B.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Misra, P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Parsa, K. V.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1CbE8FcZu8GG-_UdOqtU8A4Z4xs04r-v_/view?usp=drivesdk">https://drive.google.com/file/d/1CbE8FcZu8GG-_UdOqtU8A4Z4xs04r-v_/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-19773 25.06.2025 25.06.2025 Documentos solicitados