Inhibitory effect of Mexican oregano (Lippia graveolens Kunth)extracts on digestive enzymes in vitro, and beneficial impact on carbohydrates and lipids absorption in vivo (Record no. 53915)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03152nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625162437.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-19796 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Inhibitory effect of Mexican oregano (Lippia graveolens Kunth)extracts on digestive enzymes in vitro, and beneficial impact on carbohydrates and lipids absorption in vivo |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Journal of EthnoPharmacology, 297, p.115527, 2022 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Ethnopharmacological relevance: Although Mexican oregano inhibits digestive enzymes in vitro its effect on the absorption of carbohydrates and lipids in vivo has not been addressed. Aim of the study: Assess the effect of Mexican oregano (Lippia graveolens Kunth)on carbohydrates and lipids absorption in vivo. The antioxidant activity also was investigated. Materials and methods: Enzymatic inhibitory action of lipase, ?-amylase, and ?-glucosidase was evaluated in vitro. Oral lipid (OLTT)and starch tolerance tests (OSTT)were conducted with L. graveolens acetone (O-A)and ethanol (O-E)extracts (at 102 mg/kg body weight equivalent to a 1 g human doses)in male Wistar rats. The antioxidant activity was evaluated through inhibition of lipid peroxidation and scavenging radical. Results: Both extracts exhibited higher inhibitory median concentration (IC50)of lipase activity (1.9 ?g/?L for O-E and 1.8 ?g/?L for O-A)than the positive control (Orlistat)(0.07 ?g/?L). The IC50 of ?-amylase was higher (41.8 ?g/?L for O-E and 25.2 ?g/?L for O-A)than the Acarbose (2.5 ?g/?L); while ?-glucosidase results showed not statistically differences between groups (?1.7 ?g/?L). The OLTT results showed that both extracts significantly reduced serum triglycerides (?147 mg/dL for O-E and ?155 mg/dL for O-A)as compared with negative control group (only lipid load). In the OSTT, glucose levels showed a significant decrease (?31 mg/dL for O-E and ?17 mg/dL for O-A)than the negative control group (only starch load). About in vitro antioxidant evaluation, not statistically differences between extracts and positive control (Trolox)were observed for scavenged free radicals (?2.0 ?g/?L); whereas O-A inhibited lipid peroxidation similar to the Trolox (?0.8 ?g/?L IC50). The main chemical composition of both extracts was coumaric acid, luteolin, rutinoside, naringenin, and carvacrol. Conclusions: Both extracts reduce lipid absorption; whereas O-E decreases carbohydrate absorption in vivo. Both extracts inhibit lipid peroxidation and scavenging free radicals in vitro. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ANTIOXIDANT |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ENZYMATIC STARCH DIGESTIÓN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | HYPOGLYCEMIC |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | HYPOLIPIDEMIC |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MEXICAN OREGANO |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gamboa-Gómez, C. I. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Denise-Herrera, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Simental-Mendía, L. E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zamilpa-Alvarez, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | González-Cortazar, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Martínez-Aguilar, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Guerrero-Romero, F. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1N03ADOAuzLrX-PlfKuzBWOvX6O8VoRzd/view?usp=drivesdk">https://drive.google.com/file/d/1N03ADOAuzLrX-PlfKuzBWOvX6O8VoRzd/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-19796 | 25.06.2025 | 25.06.2025 | Documentos solicitados |