Structural Insights into Function of Ionotropic Glutamate Receptors (Record no. 53926)

MARC details
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fixed length control field 01849nam a2200337Ia 4500
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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625162437.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-19808
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245 10 - TITLE STATEMENT
Title Structural Insights into Function of Ionotropic Glutamate Receptors
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Volume/sequential designation BioChemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 16(3), p.190-206, 2022
520 3# - SUMMARY, ETC.
Summary, etc. Ionotropic glutamate receptors (iGluRs)mediate fast excitatory neurotransmission. They are implicated in nervous system development and function, while their dysfunction is associated with neurological and psychiatric disorders. In this review, we describe recent progress in structural studies of iGluRs and how crystal and cryo-EM structures helped determining the principles of iGluR architecture and assembly, and the mechanisms of activation, desensitization and regulation by auxiliary subunits, positive and negative allosteric modulators, and ion channel blockers. The new structural insights facilitate better understanding of iGluR physiological and pathophysiological roles in functioning of the central nervous system and provide valuable information for structure-based drug design.
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Topical term or geographic name entry element IGLUR
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Topical term or geographic name entry element AMPA RECEPTOR
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Topical term or geographic name entry element NMDA RECEPTOR
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Topical term or geographic name entry element KAINATE RECEPTOR
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Topical term or geographic name entry element DELTA RECEPTOR
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Topical term or geographic name entry element GLR
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Topical term or geographic name entry element AUXILIARY SUBUNIT
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Topical term or geographic name entry element GATING
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Topical term or geographic name entry element DESENSITIZATION
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Topical term or geographic name entry element CHANNEL BLOCKER
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Topical term or geographic name entry element INHIBITOR
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Topical term or geographic name entry element CRYO-EM
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Topical term or geographic name entry element X-RAY CRYSTALLOGRAPHY
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Personal name Yelshanskaya, M. V.
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Personal name Sobolevsky, A. I.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1-21ExUOHXE5eAxprWLmddIYD0Ou7TrlX/view?usp=drivesdk">https://drive.google.com/file/d/1-21ExUOHXE5eAxprWLmddIYD0Ou7TrlX/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-19808 25.06.2025 25.06.2025 Documentos solicitados