3D multi-channel bi-functionalized silk electrospun conduits for peripheral nerve regeneration (Record no. 53968)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02923nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625162438.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-19853 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | 3D multi-channel bi-functionalized silk electrospun conduits for peripheral nerve regeneration |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Journal of the mechanical behavior of biomedical Materials, 41, p.43-55, 2015 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Despite technological advances over the past 25 years, a complete recovery from peripheral nerve injuries remains unsatisfactory today. The autograft is still considered the "gold standard" in clinical practice; however, postoperative complications and limited availability of nerve tissue have motivated the development of alternative approaches. Among them, the development of biomimetic nerve graft substitutes is one of the most promising strategies. In this study, multichanneled silk electrospun conduits bi-functionalized with Nerve Growth Factor (NGF)and Ciliary Neurotropic Factor (CNTF)were fabricated to enhance peripheral nerve regeneration. These bioactive guides consisting of longitudinally oriented channels and aligned nanofibers were designed in order to mimic the fascicular architecture and fibrous extracellular matrix found in native nerve. The simple use of the electrospinning technique followed by a manual manipulation to manufacture these conduits provides tailoring of channel number and diameter size to create perineurium-like structures. Functionalization of the silk fibroin nanofiber did not affect its secondary structure and chemical property. ELISA assays showed the absence of growth factors passive release from the functionalized fibers avoiding the topical accumulation of proteins. In addition, our biomimetic multichanneled functionalized nerve guides displayed a mechanical behavior comparable to that of rat sciatic nerve with an ultimate peak stress of 4.0 ± 0.6 MPa and a corresponding elongation at failure of 156.8 ± 46.7 percent. Taken together, our results demonstrate for the first time our ability to design and characterize a bi-functionalized nerve conduit consisting of electrospun nanofibers with multichannel oriented and nanofibers aligned for peripheral regeneration. Our bioactive silk tubes thus represent a new and promising technique towards the creation of a biocompatible nerve guidance conduit. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | BIOENGINEERING |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | BIOMECHANICS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ELECTROSPINNING |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | NERVE REGENERATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | SILK |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dinis, T. M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Elia, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vidal, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dermigny, Q. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Denoeud, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kaplan, D. L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marin, F. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1XYHKteP7fhFf38-W8rXM0q-kMnfn29rj/view?usp=drivesdk">https://drive.google.com/file/d/1XYHKteP7fhFf38-W8rXM0q-kMnfn29rj/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-19853 | 25.06.2025 | 25.06.2025 | Documentos solicitados |