MARC details
| 000 -LEADER |
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02066nam a2200289Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625162442.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-20094 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Anti-influenza activity of betulinic acid from Zizyphus jujuba on influenza A/PR/8 virus |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Biomolecules & Therapeutics, 23(4), p.345-349, 2015 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Betulinic acid, a pentacyclic triterpene isolated from Jujube tree (Zizyphus jujuba Mill), has been known for a wide range of biological and medicinal properties such as antibacterial, antimalarial, anti-inflammatory, antihelmintic, antinociceptive, and anticancer activities. In the study, we investigated the antiviral activity on influenza A/PR/8 virus infected A549 human lung adenocarcinoma epithelial cell line and C57BL/6 mice. Betulinic acid showed the anti-influenza viral activity at a concentration of 50 ?M without a significant cytotoxicity in influenza A/PR/8 virus infected A549 cells. Also, betulinic acid significantly attenuated pulmonary pathology including increased necrosis, numbers of inflammatory cells and pulmonary edema induced by influenza A/PR/8 virus infection compared with vehicle- or oseltamivir-treated mice in vivo model. The down-regulation of IFN-? level, which is critical for innate and adaptive immunity in viral infection, after treating of betulinic acid in mouse lung. Based on the obtained results, it is suggested that betulinic acid can be the potential therapeutic agent for virus infection via anti-inflammatory activity. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
BETULINIC ACID |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ZIZYPHUS JUJUBA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
INFLUENZA A/PR/8 |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
A549 |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
INFLAMMATION |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hong, E. H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Song, J. H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kang, K. B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sung, S. H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Ko, H. J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Yang, H. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1GRpsusCFfyhqQz--jIVFumvQhr0rVQkB/view?usp=drivesdk">https://drive.google.com/file/d/1GRpsusCFfyhqQz--jIVFumvQhr0rVQkB/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
