MARC details
| 000 -LEADER |
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| fixed length control field |
02451nam a2200313Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625162443.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-20138 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
The reactivity of copper complexes with neuronal peptides promoted by catecholamines and its impact on neurodegeneration |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Coordination Chemistry Reviews, 471, p.214756, 2022 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
In this review we give an updated outlook of the reactivity of catecholamines, particularly dopamine, and the redox effects produced by their interaction with copper(II)and dioxygen, with emphasis to the extensive studies carried out by our group. The interaction between copper(II)ions and neuronal proteins and peptides can contribute to neurodegeneration because in many cases the peptide fragments contain high affinity binding sites and the resulting complexes exhibit increased redox reactivity. It has become apparent in recent years that the redox reactivity of Cu-peptide complexes can be substantially improved by catecholamines, which are redox reactive molecules by themselves but also relatively good ligands for copper ions. Therefore, the toxic effects of copper dyshomeostasis will be particularly harmful in the brain areas producing and releasing catecholamines, i.e. the axon terminals of the substantia nigra and locus coeruleus. These are the brain regions which become affected in the early stages of Parkinson and Alzheimer's disease, indicating that copper neurotoxicity may contribute to the outset of the diseases. Copper-?-amyloid and copper-prion complexes exhibit the highest redox activity induced by catecholamines; their reactivity is modulated by interaction with membranes, which tend to depress the reactivity unless the peptides interact with each other strengthening the binding of copper(II). |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
COPPER-PEPTIDE COMPLEXES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
DOPAMINE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
OXIDATIVE STRESS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
?-AMYLOID |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PRION PROTEIN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
A-SYNUCLEIN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TAU PROTEIN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
QUINONE-PROTEIN MODIFICATION |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Bacchella, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Dell'Acqua, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Nicolis, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Monzani, E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Casella, L. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/12NS11ndFtbT_1flqyW5xEAraQNC3IBVO/view?usp=drivesdk">https://drive.google.com/file/d/12NS11ndFtbT_1flqyW5xEAraQNC3IBVO/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
