Effect of chlorhexidine-containing detergent, non-medicated soap or isopropanol and the influence of neutralizer on bacterial pathogenicity (Record no. 54268)

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control field 20250625162444.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-20165
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245 10 - TITLE STATEMENT
Title Effect of chlorhexidine-containing detergent, non-medicated soap or isopropanol and the influence of neutralizer on bacterial pathogenicity
490 0# - SERIES STATEMENT
Volume/sequential designation Journal of Hospital Infection, 11(3), p.220-225, 1988
520 3# - SUMMARY, ETC.
Summary, etc. In handwashing experiments with Salmonella typhimurium the effect of chlorhexidine (CHX)on the pathogenicity of surviving bacteria was assessed with and without a neutralizer in a mouse model of infection. Without neutralizer the LD50 of CHX handwash fluids was raised. Neutralizer in suspensions of untreated bacteria caused a reduction of LD50 up to 1.2 logs. Thus, in contrast to soap or alcohol, CHX without neutralizer exerted a slight 'depathogenizing' action and neutralizer a slight 'pathogenizing' effect in the experimental model used. However, in comparison to the efficiency of handwashing procedures which reduce the number of bacteria available for transfer by at least 3.0 to 4.2 logs, the size of these effects seems to be negligibly small and unpredictable. Therefore, the single most important parameter in assessing the potency of disinfectants remains the reduction of viable counts with time.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CHLORHEXIDINE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HANDWASHING
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PATHOGENICITY
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Rotter, M. L.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Hirschl, A. M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Koller, W.
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-20165 25.06.2025 25.06.2025 Documentos solicitados