Antimicrobial and anti-inflammatory drug-delivery systems at endodontic reparative material: synthesis and characterization (Record no. 54301)

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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625162444.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-20198
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245 10 - TITLE STATEMENT
Title Antimicrobial and anti-inflammatory drug-delivery systems at endodontic reparative material: synthesis and characterization
490 0# - SERIES STATEMENT
Volume/sequential designation Dental Materials, 35(3), p.457-467, 2019
520 3# - SUMMARY, ETC.
Summary, etc. Objective: The aim of this study was to synthesize and characterize an experimental endodontic paste. Methods: An experimental endodontic paste (EX)was characterized by its particle size, zeta potential, drug content and morphology. The powder of EX is composed of amoxicillin microspheres, calcium tungstate and ?-tricalcium phosphate, mixed with an indomethacin nanocapsules suspension. Ultracal® (Ultradent), an iodoform-based paste (GP)and the EX were evaluated by its physical properties (flow, film thickness and radiopacity). The cytocompatibility was performed by MTT and SRB-colorimetric assays; the cell-migration was tested with scratch assay and cell-ability to remineralization with ALP and Alizarin Red S, with fibroblastic cell line. The antibacterial activity was assessed by the formation of inhibition zones and against planktonic bacteria. Results: The EX and UL flow achieved ISO6876 standard, and GP was lower than 17mm. All pastes achieved the film thickness required. Radiopacity was equivalent to 1.81±0.25mmAl for EX, which did not differ from GP group 1.39±0.33mmAl (p>0.05). The UL presented 3.04±0.33mmAl. The values for SRB showed better citocompatibility in comparison with MTT for all materials. The ALP activity and formation of mineralized nodules demonstrated the remineralization potential for UL and EX. Cell migration showed continuous wound closure until complete cell healing, however, the EX accelerated the process (p<0.05). The EX showed the greatest inhibition zone (p<0.05)and was the only group with antibacterial activity against planktonic bacteria.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element AMOXICILLIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BIOACTIVITY
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BIOCOMPATIBILITY
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element DRUG DELIVERY SYSTEMS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element INDOMETHACIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element MICROSPHERES
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element NANOCAPSULES
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Cuppini, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Zatta, K. C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Mestieri, L. B.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Grecca, F. S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Leitune, V. C. B.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Guterres, S. S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Collares, F. M.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1_q58E0mEYih-M4D-mwzFlsJaOOna5dXM/view?usp=drivesdk">https://drive.google.com/file/d/1_q58E0mEYih-M4D-mwzFlsJaOOna5dXM/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-20198 25.06.2025 25.06.2025 Documentos solicitados