Engineered skin bacteria induce antitumor T cell responses against melanoma (Record no. 54367)

MARC details
000 -LEADER
fixed length control field 01652nam a2200241Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625162445.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-20268
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250602s9999 xx |||||s2 |||| ||und|d
245 10 - TITLE STATEMENT
Title Engineered skin bacteria induce antitumor T cell responses against melanoma
490 0# - SERIES STATEMENT
Volume/sequential designation Science, 380(6641), p.203-210, 2023
520 3# - SUMMARY, ETC.
Summary, etc. Certain bacterial colonists induce a highly specific T cell response. A hallmark of this encounter is that adaptive immunity develops preemptively, in the absence of an infection. However, the functional properties of colonist-induced T cells are not well defined, limiting our ability to understand anticommensal immunity and harness it therapeutically. We addressed both challenges by engineering the skin bacterium Staphylococcus epidermidis to express tumor antigens anchored to secreted or cell-surface proteins. Upon colonization, engineered S. epidermidis elicits tumor-specific T cells that circulate, infiltrate local and metastatic lesions, and exert cytotoxic activity. Thus, the immune response to a skin colonist can promote cellular immunity at a distal site and can be redirected against a target of therapeutic interest by expressing a target-derived antigen in a commensal.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Chen, Y. E.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Bousbaine, D.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Veinbachs, A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Atabakhsh, K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Dimas, A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Yu, V. K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Fischbach, M. A.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1ioEy2yAZ88PB1Aj_vGSEmF4almT_qoSX/view?usp=drivesdk">https://drive.google.com/file/d/1ioEy2yAZ88PB1Aj_vGSEmF4almT_qoSX/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-20268 25.06.2025 25.06.2025 Documentos solicitados