Therapeutic potential of essential oils in Acanthamoeba keratitis (Record no. 54423)

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fixed length control field 02018nam a2200241Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625162447.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-20326
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
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245 10 - TITLE STATEMENT
Title Therapeutic potential of essential oils in Acanthamoeba keratitis
490 0# - SERIES STATEMENT
Volume/sequential designation PhytoChemistry Reviews, 22(3), p.543-563, 2023
520 3# - SUMMARY, ETC.
Summary, etc. New therapeutic agents for amoebic keratitis are needed considering that drugs currently marketed are toxic and not effective against protozoan cystic forms. The antimicrobial action of essential oils (EOs)is already reported in the literature, which has motivated investigations of their anti-Acanthamoeba potential. Unlike synthetic drugs, plant materials have been often identified as less cytotoxic. In this review, the anti-Acanthamoeba potential of EOs was demonstrated not only based on the anti-protozoan activity as anti-inflammatory activity. Finally, in vitro cytotoxicity studies of EOs active were analyzed. EOs were able to prevent the conversion of the protozoan trophozoite to cystic form. In a study performed with Trachyspermum ammi EO, 100percent of Acanthamoeba cysts were eliminated. Thymus capitatus and Limonium oleifolium EOs showed to be more active against Acanthamoeba, presenting IC50 values close to chlorhexidine and lower than amphotericin B. For these two OEs, low in vitro cytotoxicity was also found, which result in a high selectivity index (SI?>?10). Therefore, safer and more effective therapies could be achieved with OEs, and in vivo assays should be urgently performed to confirm these benefits.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ACANTHAMOEBA KERATITIS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ESSENTIAL OILS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CYTOTOXICITY
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ANTI-INFLAMMATORY ACTION
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Porto, D. S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Caumo, K. S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Caon, T.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1gfFol9hVTsPHxlWt9YK1pwLVmdCerKBH/view?usp=drivesdk">https://drive.google.com/file/d/1gfFol9hVTsPHxlWt9YK1pwLVmdCerKBH/view?usp=drivesdk</a>
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942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-20326 25.06.2025 25.06.2025 Documentos solicitados