Estimating genomic distance from DNA sequence location in cell nuclei by a random walk model (Record no. 54433)
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| fixed length control field | 01634nam a2200193Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625162447.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-20337 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Estimating genomic distance from DNA sequence location in cell nuclei by a random walk model |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Science, 257(5075), p.1410-1412, 1992 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The folding of chromatin in interphase cell nuclei was studied by fluorescent in situ hybridization with pairs of unique DNA sequence probes. The sites of DNA sequences separated by 100 to 2000 kilobase pairs (kbp)are distributed in interphase chromatin according to a random walk model. This model provides the basis for calculating the spacing of sequences along the linear DNA molecule from interphase distance measurements. An interphase mapping strategy based on this model was tested with 13 probes from a 4-megabase pair (Mbp)region of chromosome 4 containing the Huntington disease locus. The results confirmed the locations of the probes and showed that the remaining gap in the published maps of this region is negligible in size. Interphase distance measurements should facilitate construction of chromosome maps with an average marker density of one per 100 kbp, approximately ten times greater than that achieved by hybridization to metaphase chromosomes. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Van Den Engh, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sachs, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Trask, B. J. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1dGt6NaR-OG7GjiZkIq_RLfLsBzSJ32Hq/view?usp=drivesdk">https://drive.google.com/file/d/1dGt6NaR-OG7GjiZkIq_RLfLsBzSJ32Hq/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-20337 | 25.06.2025 | 25.06.2025 | Documentos solicitados |