MARC details
| 000 -LEADER |
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| fixed length control field |
02947nam a2200253Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625162448.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-20389 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Zwitterionization of common hemodialysis membranes: Assessment of different immobilized structure impact on hydrophilicity and biocompatibility of poly aryl ether sulfone (PAES)and cellulose triacetate (CTA)hemodialysis membranes |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Structural Chemistry, 33(6), p.1965-1982, 2022 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Hemodialysis (HD)membrane materials-blood hemocompatibility is considered as the most important reason for intra- and post hemodialysis complications. The incompatibility could result in different cascade activations due to the interactions between vital human serum proteins (HSPs)and HD membranes. This study aims to assess the interaction energy between common hemodialysis polymer structures in the zwitterionized state and HSPs using molecular dynamics (MD)simulation to offer a framework for understanding the dominant interactions as a reference for HD material development. To perform zwitterionization, a feasible mussel-inspired methodology was used. Poly aryl ether sulfone (PAES)and cellulose triacetate (CTA)were chosen for the base membrane models and carboxybetaine methacrylate (CBMA), sulfobetaine methacrylate (SBMA), and phosphobetaine methacrylate (PBMA)were picked as common zwitterionic structures (ZWs)for surface modification. Human serum albumin (HSA), fibrinogen (FB), and transferrin (TRF)were selected as the models of HSPs. Polydopamine (PDA)was used for the binding structure. The binding energy of the membrane models and selected proteins, as well as the hydrophilicity of the membrane models, was assessed. Hydrophilicity assessment of the membrane models suggests that PBMA creates more tendency to water molecules when the modifying layer is located on both CTA- and PAES-based membrane models. The results suggest that the hemocompatibility of the membranes does not directly correlate with the hydrophilicity of the polymeric structures. While each protein creates a specific trend when interacting with membrane models with different base polymers and modifying layers, natural biomolecules such as PDA or carboxybetaine structures are suggested to eliminate FB's interactions. For biocompatibility enhancement, as well as hydrophilicity enhancement, sulfo- and phosphobetaine-containing coatings could be used. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
HEMODIALYSIS MEMBRANE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MOLECULAR DYNAMICS SIMULATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
INTERACTION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
BINDING ENERGY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ZWITTERIONIZATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
HYDROPHILICITY |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Mollahosseini, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Abdelrasoul, A. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1wn_I5JKZr7LVkWTCycvZzOMZxnrTU9mb/view?usp=drivesdk">https://drive.google.com/file/d/1wn_I5JKZr7LVkWTCycvZzOMZxnrTU9mb/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
