Investigation of targets and anticancer mechanisms of covalently acting natural products by functional proteomics (Record no. 54496)
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| 000 -LEADER | |
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| fixed length control field | 02343nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625162448.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-20401 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Investigation of targets and anticancer mechanisms of covalently acting natural products by functional proteomics |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Acta Pharmacologica Sinica, 44, p.1701-1711, 2023 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Eriocalyxin B (EB), 17-hydroxy-jolkinolide B (HJB), parthenolide (PN), xanthatin (XT)and andrographolide (AG)are terpenoid natural products with a variety of promising antitumor activities, which commonly bear electrophilic groups (?,?-unsaturated carbonyl groups and/or epoxides)capable of covalently modifying protein cysteine residues. However, their direct targets and underlying molecular mechanisms are still largely unclear, which limits the development of these compounds. In this study, we integrated activity-based protein profiling (ABPP)and quantitative proteomics approach to systematically characterize the covalent targets of these natural products and their involved cellular pathways. We first demonstrated the anti-proliferation activities of these five compounds in triple-negative breast cancer cell MDA-MB-231. Tandem mass tag (TMT)-based quantitative proteomics showed all five compounds commonly affected the ubiquitin mediated proteolysis pathways. ABPP platform identified the preferentially modified targets of EB and PN, two natural products with high anti-proliferation activity. Biochemical experiments showed that PN inhibited the cell proliferation through targeting ubiquitin carboxyl-terminal hydrolase 10 (USP10). Together, this study uncovered the covalently modified targets of these natural products and potential molecular mechanisms of their antitumor activities. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | NATURAL PRODUCTS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PROTEOMICS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ABPP |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ERIOCALYXIN B |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PARTHENOLIDE |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhao, W. S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, K. F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liu, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jia, X. L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Huang, Y. Q. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hao, B. B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tan, M. J. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1vfmWhE20oAretUfk_-8MpNMCmlk2z-JN/view?usp=drivesdk">https://drive.google.com/file/d/1vfmWhE20oAretUfk_-8MpNMCmlk2z-JN/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-20401 | 25.06.2025 | 25.06.2025 | Documentos solicitados |