In vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae) (Record no. 54523)

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control field 20250625162448.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-20431
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245 10 - TITLE STATEMENT
Title In vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae)
490 0# - SERIES STATEMENT
Volume/sequential designation Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 21(7), p.671-674, 2007
520 3# - SUMMARY, ETC.
Summary, etc. In this study the methanol/dichloromethane (1:1)extract and plumbagin isolated from extract of stem barks of Diospyros crassiflora were tested for their antifungal activity against 12 strains of yeast pathogens and filamentous fungi: Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis, Cryptococcus neoformans, Aspergillus niger, Aspergillus flavus, Alternaria sp., Cladosporium sp., Geotrichum candidum, Fusarium sp. and Penicillium sp. The growth of all fungi strains tested was inhibited by the extract and plumbagin. The diameter of inhibition zones varied from 12 to 18 mm and from 21 to 35 mm for the extract and plumbagin, respectively. The MIC values ranged from 12.5 to 25 mg/mL for the extract and 0.78-3.12 microg/mL for plumbagin. It is therefore suggested that extracts from the stem bark of Diospyros crassiflora could be used traditionally in the treatment of fungal infections. Compared with ketoconazole used as a standard antifungal, plumbagin could be considered as a promising antifungal agent.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element DIOSPYROS CRASSIFLORA
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element EBENACEAE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PLUMBAGIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ANTIFUNGAL ACTIVITY
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Dzoyem, J. P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Tangmouo, J. G.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Lontsi, D.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Etoa, F. X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Lohoue, P. J.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1BM2LylQjCoWmkZ623wwu-Z0pMbkW03eG/view?usp=drivesdk">https://drive.google.com/file/d/1BM2LylQjCoWmkZ623wwu-Z0pMbkW03eG/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-20431 25.06.2025 25.06.2025 Documentos solicitados