The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation (Record no. 54708)

MARC details
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fixed length control field 01599nam a2200229Ia 4500
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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625162452.0
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Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-20622
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Title The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
490 0# - SERIES STATEMENT
Volume/sequential designation Science, 381(6660), p.eadh5021, 2023
520 3# - SUMMARY, ETC.
Summary, etc. Cells use ubiquitin to mark proteins for proteasomal degradation. Although the proteasome also eliminates proteins that are not ubiquitinated, how this occurs mechanistically is unclear. Here, we found that midnolin promoted the destruction of many nuclear proteins, including transcription factors encoded by the immediate-early genes. Diverse stimuli induced midnolin, and its overexpression was sufficient to cause the degradation of its targets by a mechanism that did not require ubiquitination. Instead, midnolin associated with the proteasome via an ? helix, used its Catch domain to bind a region within substrates that can form a ? strand, and used a ubiquitin-like domain to promote substrate destruction. Thus, midnolin contains three regions that function in concert to target a large set of nuclear proteins to the proteasome for degradation.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Gu, X.
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Personal name Nardone, C.
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Personal name Kamitaki, N.
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Personal name Mao, A.
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Personal name Elledge, S. J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Greenberg, M. E.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1xKet5r2rKS71fKnn_E2zfhjW_QS4ztFS/view?usp=drivesdk">https://drive.google.com/file/d/1xKet5r2rKS71fKnn_E2zfhjW_QS4ztFS/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-20622 25.06.2025 25.06.2025 Documentos solicitados